Relationship Between Gut Microbiome and Mucosal Health and Its Impact on Intestinal Immunity in Dairy Cows

Authors

  • Thiheebah Mansour Department of Zoology, Faculty of Sciences, Aljafra University, Almamura ,Libya Author
  • Amhmimmid Alkeesh Department of Biology, Faculty of Education , Alzintan University , Yeffran , Libya Author

Keywords:

Gut microbiome, microbial diversity, mucosal health, intestinal immunity

Abstract

The mucosal barrier, which offers both physical and immunological defense against infections, interacts closely with the gut microbiota in dairy cows, which is essential for digestion, nutrient absorption, and intestinal health maintenance. Theoretical frameworks highlight the importance of a diversified and balanced microbial population, which is dominated by phyla like Bacteroidetes and Firmicutes, in promoting disease resistance and host resilience. Conceptual models illustrate the beneficial connections between microbial balance, mucosal health, and immune function by indicating that optimum microbial diversity is linked to improved intestinal immunity and greater mucosal integrity. These findings highlight how crucial it is to keep the gut microbiota consistent in order to support immunological resilience, avoid dysbiosis, and guarantee successful host–microbe interactions in dairy cows—all of which improve general health and productivity.

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References

Plaizier, J. C., Mesgaran, M. D., Derakhshani, H., Golder, H., Khafipour, E., Kleen, J. L., ... & Zebeli, Q. (2018). Enhancing gastrointestinal health in dairy cows. Animal, 12(s2), s399-s418.‏

Taschuk, R., & Griebel, P. J. (2012). Commensal microbiome effects on mucosal immune system development in the ruminant gastrointestinal tract. Animal health research reviews, 13(1), 129-141.‏

Lai, Z., Lin, L., Zhang, J., & Mao, S. (2022). Effects of high-grain diet feeding on mucosa-associated bacterial community and gene expression of tight junction proteins and inflammatory cytokines in the small intestine of dairy cattle. Journal of dairy science, 105(8), 6601-6615.‏

Pitta, D. W., Indugu, N., Kumar, S., Vecchiarelli, B., Sinha, R., Baker, L. D., ... & Ferguson, J. D. (2016). Metagenomic assessment of the functional potential of the rumen microbiome in Holstein dairy cows. Anaerobe, 38, 50-60.‏

Deering, K. E., Devine, A., O’Sullivan, T. A., Lo, J., Boyce, M. C., & Christophersen, C. T. (2019). Characterizing the composition of the pediatric gut microbiome: a systematic review. Nutrients, 12(1), 16.‏

Pinart, M., Dötsch, A., Schlicht, K., Laudes, M., Bouwman, J., Forslund, S. K., ... & Nimptsch, K. (2021). Gut microbiome composition in obese and non-obese persons: a systematic review and meta-analysis. Nutrients, 14(1), 12.‏

Gupta, V. K., Paul, S., & Dutta, C. (2017). Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity. Frontiers in microbiology, 8, 1162.‏

Wen, L., & Duffy, A. (2017). Factors influencing the gut microbiota, inflammation, and type 2 diabetes. The Journal of nutrition, 147(7), 1468S-1475S.‏

Vandenplas, Y., Carnielli, V. P., Ksiazyk, J., Luna, M. S., Migacheva, N., Mosselmans, J. M., ... & Wabitsch, M. (2020). Factors affecting early-life intestinal microbiota development. Nutrition, 78, 110812.‏

Bajinka, O., Tan, Y., Abdelhalim, K. A., Özdemir, G., & Qiu, X. (2020). Extrinsic factors influencing gut microbes, the immediate consequences and restoring eubiosis. Amb Express, 10(1), 130.‏

Hasan, N., & Yang, H. (2019). Factors affecting the composition of the gut microbiota, and its modulation. PeerJ, 7, e7502.‏

Turner, J. R. (2009). Intestinal mucosal barrier function in health and disease. Nature reviews immunology, 9(11), 799-809.‏

Okumura, R., & Takeda, K. (2018). Maintenance of intestinal homeostasis by mucosal barriers. Inflammation and regeneration, 38(1), 5.‏

Di Sabatino, A., Santacroce, G., Rossi, C. M., Broglio, G., & Lenti, M. V. (2023). Role of mucosal immunity and epithelial–vascular barrier in modulating gut homeostasis. Internal and emergency medicine, 18(6), 1635-1646.‏

Sanchez de Medina, F., Romero-Calvo, I., Mascaraque, C., & Martínez-Augustin, O. (2014). Intestinal inflammation and mucosal barrier function. Inflammatory bowel diseases, 20(12), 2394-2404.‏

Breugelmans, T., Oosterlinck, B., Arras, W., Ceuleers, H., De Man, J., Hold, G. L., ... & Smet, A. (2022). The role of mucins in gastrointestinal barrier function during health and disease. The Lancet Gastroenterology & Hepatology, 7(5), 455-471.‏

Geuking, M. B., Köller, Y., Rupp, S., & McCoy, K. D. (2014). The interplay between the gut microbiota and the immune system. Gut microbes, 5(3), 411-418.‏

Yiu, J. H., Dorweiler, B., & Woo, C. W. (2017). Interaction between gut microbiota and toll-like receptor: from immunity to metabolism. Journal of Molecular Medicine, 95(1), 13-20.‏

Shi, N., Li, N., Duan, X., & Niu, H. (2017). Interaction between the gut microbiome and mucosal immune system. Military Medical Research, 4(1), 14.‏

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Published

2025-10-18

How to Cite

Relationship Between Gut Microbiome and Mucosal Health and Its Impact on Intestinal Immunity in Dairy Cows. (2025). Comprehensive Journal of Science, 9(36), 33-40. https://cjos.histr.edu.ly/index.php/journal/article/view/114