Sensitivity of Urinary Tract Infection E. coli to Amoxicillin, Ciprofloxacin, Cefotaxime, and Ceftriaxone in Tarhuna City
DOI:
https://doi.org/10.65405/cjos.2025.786الكلمات المفتاحية:
antibiotic, susceptibility, E. coli , MacConkey, API 20E, disc diffusionالملخص
A cross-sectional study was conducted to determine the antibiotic susceptibility of E. coli isolates from 130 patients (both genders) presenting with urinary tract infections (UTIs). The study employed standard microbiological techniques for pathogen isolation and identification, including growth on MacConkey agar and confirmation with the API 20E system. The Kirby-Bauer disc diffusion method was used to assess the susceptibility of the isolates to various antibiotics. Results showed an alarmingly high rate of resistance to commonly prescribed antibiotics. Of the isolates, only 45 were sensitive to Amoxicillin (34.6%), while 6 were sensitive to Ciprofloxacin (4.6%). The findings indicate that the efficacy of these first-line agents for the empirical treatment of UTIs has been significantly compromised in the studied population. This highlights a critical need for updated treatment guidelines and robust antibiotic stewardship to combat the growing public health threat of antibiotic resistance.
التنزيلات
المراجع
Bittencourt, A. A., Paula, M. D. N. D., Ribeiro-Pereira, A. C. P., Batista, P. D. M., & Polis, T. J. (2025). An integrative review on treatment guidelines for complicated urinary tract infections: a synthesis of evidence-based recommendations. Revista do Instituto de Medicina Tropical de São Paulo, 67, e7.
Garrido, D., Garrido, S., Gutiérrez, M., Calvopiña, L., Sunday Harrison, A., Fuseau, M., & Salazar Irigoyen, R. (2017). Clinical characterization and antimicrobial resistance of Escherichia coli in pediatric patients with urinary tract infection at a third level hospital of Quito, Ecuador. Boletin Medico Del Hospital Infantil de Mexico, 74(4), 265-271.
Isac, R., Basaca, D. G., Olariu, I. C., Stroescu, R. F., Ardelean, A. M., Steflea, R. M., ... & Doros, G. (2021). Antibiotic resistance patterns of uropathogens causing urinary tract infections in children with congenital anomalies of kidney and urinary tract. Children, 8(7), 585.
Nalini, R., Meenakshi, B., & Ramya, J. E. (2013, December). Recent sensitivity pattern of Escherichia Coli in urinary tract infection. In Indian Journal of Pharmacology (Vol. 45, pp. S194-S194).
Naqid, I. A., Balatay, A. A., Hussein, N. R., Saeed, K. A., Ahmed, H. A., & Yousif, S. H. (2020). Antibiotic susceptibility pattern of Escherichia coli isolated from various clinical samples in Duhok City, Kurdistan Region of Iraq. Int J Infect, 7(3), e103740.Karger Publishers. (2020). Antimicrobial Susceptibility Patterns of Escherichia coli among Tunisian Outpatients with Community-Acquired Urinary Tract Infection (2012-2018).
Prakash, D., et al. (2016). Recent Trends in the Prevalence of Uropathogens and Their Antimicrobial Susceptibility Pattern: A Review. Journal of Medical and Health Sciences, 5(1), 1-10.
Rossi, B., Soubirou, J. F., Chau, F., Massias, L., Dion, S., Lepeule, R., ... & Lefort, A. (2016). Cefotaxime and amoxicillin-clavulanate synergism against extended-spectrum-β-lactamase-producing Escherichia coli in a murine model of urinary tract infection. Antimicrobial Agents and Chemotherapy, 60(1), 424-430.
التنزيلات
منشور
إصدار
القسم
الرخصة
الحقوق الفكرية (c) 2025 مجلة العلوم الشاملة
هذا العمل مرخص بموجب Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
