Prediction of Preeclampsia Using Maternal Factors, Biochemical Markers, and Uterine Artery Doppler

Authors

  • Ruwaydah Abuojaylah Albakoush Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sabratha, Sabratha, Libya Author
  • Azab Elsayed Azab Department of Physiology, Faculty of Medicine, University of Sabratha, Sabratha, Libya Author
  • Amal ElBasher Eltome Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sabratha, Sabratha, Libya Author

DOI:

https://doi.org/10.65405/dravnk45

Keywords:

Preeclampsia; Uterine Artery Doppler; Obstetrics

Abstract

Pregnancy-related hypertensive diseases are a major global cause of maternal and perinatal death. Preeclampsia (PE) is a pregnancy disease that often manifests after 20 weeks of gestation and generally occurs close to term.Our aim of work was to achieve early prediction of preeclampsia using maternal factors, biochemical markers, and uterine artery doppler. This review was conducted following a narrative review approach via searching many databases such as PubMed, Scopus and Google Scholar. We came to the conclusion that early diagnosis, timely medical management, and adequate surveillance and monitoring are imperative to decreasing both maternal and fetal morbidity and mortality associated with preeclampsia. The early prediction of preeclampsia can be achieved using an integrated model involving analysis of the maternal factors, biochemical markers, and uterine artery doppler. Further studies must be done to analyze all aspects of this issue.

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References

1. Martini, C., Saeed, Z., Simeone, P., Palma, S., Ricci, M., Arata, A., ... & Renda, G. (2025). Preeclampsia: Insights into pathophysiological mechanisms and preventive strategies. American Journal of Preventive Cardiology, 23, 101054.

2. Karrar, S. A., Martingano, D. J., & Hong, P. L. (2024). Preeclampsia. In StatPearls. StatPearls Publishing.

3. Magee, L. A., Nicolaides, K. H., & Von Dadelszen, P. (2022). Preeclampsia. New England Journal of Medicine, 386(19), 1817-1832.

4. Jung, E., Romero, R., Yeo, L., Gomez-Lopez, N., Chaemsaithong, P., Jaovisidha, A., ... & Erez, O. (2022). The etiology of preeclampsia. American journal of obstetrics and gynecology, 226(2), S844-S866.

5. Nirupama, R., Divyashree, S., Janhavi, P., Muthukumar, S. P., & Ravindra, P. V. (2021). Preeclampsia: Pathophysiology and management. Journal of gynecology obstetrics and human reproduction, 50(2), 101975.

6. Ma’ayeh, M., & Costantine, M. M. (2020, October). Prevention of preeclampsia. In Seminars in Fetal and Neonatal Medicine (Vol. 25, No. 5, p. 101123). WB Saunders.

7. Overton, E., Tobes, D., & Lee, A. (2022). Preeclampsia diagnosis and management. Best practice & research Clinical anaesthesiology, 36(1), 107-121.

8. Brownfoot, F., & Rolnik, D. L. (2024). Prevention of preeclampsia. Best Practice & Research Clinical Obstetrics & Gynaecology, 93, 102481.

9. Roberts, J. M. (2024). Preeclampsia epidemiology (ies) and pathophysiology (ies). Best practice & research Clinical obstetrics & gynaecology, 94, 102480.

10. Torres-Torres, J., Espino-y-Sosa, S., Martinez-Portilla, R., Borboa-Olivares, H., Estrada-Gutierrez, G., Acevedo-Gallegos, S., ... & Rojas-Zepeda, L. (2024). A narrative review on the pathophysiology of preeclampsia. International Journal of Molecular Sciences, 25(14), 7569.

11. Deer, E., Herrock, O., Campbell, N., Cornelius, D., Fitzgerald, S., Amaral, L. M., & LaMarca, B. (2023). The role of immune cells and mediators in preeclampsia. Nature Reviews Nephrology, 19(4), 257-270.

12. Ali, M., Ahmed, M., Memon, M., Chandio, F., Shaikh, Q., Parveen, A., & Phull, A. R. (2024). Preeclampsia: A comprehensive review. Clinica Chimica Acta, 563, 119922.

13. Bokuda, K., & Ichihara, A. (2023). Preeclampsia up to date—What’s going on?. Hypertension Research, 46(8), 1900-1907.

14. Boulanger, H., Bounan, S., Mahdhi, A., Drouin, D., Ahriz-Saksi, S., Guimiot, F., & Rouas-Freiss, N. (2024). Immunologic aspects of preeclampsia. AJOG Global Reports, 4(1), 100321.

15. Anderson, U. D., Olsson, M. G., Kristensen, K. H., Åkerström, B., & Hansson, S. R. (2012). Biochemical markers to predict preeclampsia. Placenta, 33, S42-S47.

16. Tzanaki, I., Makrigiannakis, A., Lymperopoulou, C., Al-Jazrawi, Z., & Agouridis, A. P. (2025). Pregnancy-associated plasma protein A (PAPP-A) as a first trimester serum biomarker for preeclampsia screening: a systematic review and meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine, 38(1), 2448502.

17. Uriel, M., Romero Infante, X. C., Rincón Franco, S., Ibáñez Pinilla, E. A., & Rojas, N. A. (2023). Higher PAPP-A values in pregnant women complicated with preeclampsia than with gestational hypertension. Reproductive Sciences, 30(8), 2503-2511.

18. Bellos, I., Pergialiotis, V., Loutradis, D., Papapanagiotou, A., & Daskalakis, G. (2020). The role of hemoglobin degradation pathway in preeclampsia: A systematic review and meta-analysis. Placenta, 92, 9-16.

19. Palei, A., Johnson, V., Everman, S., & Kutcher, M. (2025). Soluble FMS-Like Tyrosine Kinase-1 (sFLT-1) and Soluble Endoglin (sEng) Induce Platelet Hyperfunction in a Rat Model of Severe Preeclampsia. Physiology, 40(S1), 0286.

20. Droge, L. A., Perschel, F. H., Stütz, N., Gafron, A., Frank, L., Busjahn, A., ... & Verlohren, S. (2021). Prediction of preeclampsia-related adverse outcomes with the sFlt-1 (soluble fms-like tyrosine kinase 1)/PlGF (placental growth factor)-ratio in the clinical routine: a real-world study. Hypertension, 77(2), 461-471.

21. Alshannag, F., Zaki, R. M., Hemida, E., ElBakry, M. M., & Noureldeen, A. F. (2023). Endostatin and cystatin C as potential biomarkers for early prediction of preeclampsia. ACS omega, 8(45), 42776-42786.

22. Acharya, A. (2016). Promising biomarkers for superimposed pre-eclampsia in pregnant women with established hypertension and chronic kidney disease. Kidney International, 89(4), 743-746.

23. Pedroso, M. A., Palmer, K. R., Hodges, R. J., da Silva Costa, F., & Rolnik, D. L. (2018). Uterine artery Doppler in screening for preeclampsia and fetal growth restriction. Revista Brasileira de Ginecologia e Obstetrícia/RBGO Gynecology and Obstetrics, 40(05), 287-293.

24. Oancea, M., Grigore, M., Ciortea, R., Diculescu, D., Bodean, D., Bucuri, C., ... & Mihu, D. (2020). Uterine artery Doppler ultrasonography for first trimester prediction of preeclampsia in individuals at risk from low-resource settings. Medicina, 56(9), 428.

25. Cnossen, J. S., Morris, R. K., Ter Riet, G., Mol, B. W., Van Der Post, J. A., Coomarasamy, A., ... & Khan, K. S. (2008). Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. Cmaj, 178(6), 701-711.

26. Napolitano, R., Rajakulasingam, R., Memmo, A., Bhide, A., & Thilaganathan, B. (2011). Uterine artery Doppler screening for pre‐eclampsia: comparison of the lower, mean and higher first‐trimester pulsatility indices. Ultrasound in obstetrics & gynecology, 37(5), 534-537.

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Published

2026-06-14

How to Cite

Prediction of Preeclampsia Using Maternal Factors, Biochemical Markers, and Uterine Artery Doppler. (2026). Comprehensive Journal of Science, 11(41), 777-784. https://doi.org/10.65405/dravnk45

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