Effect of pH and Temperature on the degradation of ciprofloxacin and ofloxacin in aqueous solution.
DOI:
https://doi.org/10.65405/.v10i37.622Keywords:
Ofloxacin ,Ciprofloxacin, Fluoroquinolones, UV-Vis Spectrophotometer , pH Effect ,Absorbance, λ max (Maximum Wavelength)Abstract
This study aims to evaluate the impact of physical and chemical factors specifically pH and
temperature—on the stability and degradation of two fluoroquinolone antibiotics: Ofloxacin and
Ciprofloxacin in aqueous solutions. Standard solutions of varying concentrations were prepared,
and their absorbance and maximum wavelength (λ max) were measured using a UV-Vis
spectrophotometer under different pH and temperature conditions.The results showed that an acidic
medium (pH = 4) increased the absorbance of both antibiotics, with slight changes in λ max.
Elevated temperatures led to a decrease in absorbance, indicating gradual thermal degradation of
the compounds.The study highlights the importance of understanding environmental influences on
antibiotic efficacy and recommends further research involving additional factors and longer
exposure periods to enhance pharmaceutical stability assessments.
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